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49ers 48-27 Colts (23 Dec, 2025) Game Recap
INDIANAPOLIS — — Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers' final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory over the Indianapolis Colts on Monday night.
Purdy was 25 of 34 for 295 yards with one interception. Christian McCaffrey rushed 21 times for 117 yards and caught six passes for 29 yards and two scores. George Kittle had seven receptions for 115 yards and one TD.
The 49ers (11-4) won their fifth straight to stay in the chase for the NFC's top seed, one day after clinching a playoff spot by virtue of Detroit’s loss to Pittsburgh. San Francisco also snapped a five-game losing streak in the series, beating Indy for the first time since Jim Mora's infamous “playoffs” rant in November 2001.
49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers' season debut at home in 48-27 win
Philip Rivers is a fun story. On Monday night, everyone seemed to rally around the tale of a 44-year-old who was coaching high school football coming back to the NFL for the first time since the 2020 season, and actually playing well against the San Francisco 49ers.
With all the hoopla for Rivers, you might not have realized the Colts didn’t win the game.
The San Francisco 49ers are a pretty good story too. They have battled injuries all season, including season-ending ones to their two best defensive players in Nick Bosa and Fred Warner. Monday night’s 48-27 win improved their record to 11-4.
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49ers vs. Colts MNF Highlights: Purdy's Career Night, Rivers Pick-6 Sinks Indy
Two of the NFL's best headlined a Week 16 matchup with playoff implications, as Christian McCaffrey and the San Francisco 49ers defeated Jonathan Taylor and the Indianapolis Colts, 48-27, at Lucas Oil Stadium.
McCaffrey outdueled Taylor, who entered Monday Night Football ranked second in rushing yards (1,443), and Brock Purdy turned in a career-best effort to lead the Niners to a big win.
Purdy's performance gave him the edge in an intriguing quarterback battle against 44-year-old Philip Rivers, who played valiantly in his second game after a five-year retirement. The 49ers (11-4) secured a playoff berth Sunday and have now improved their chances at the No. 1 seed by beating a scrappy 8-7 Colts team that may end up missing the postseason.
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