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The Benefits and Limits of Enlicitide, With Ninel Hovnanians, MD
Hovnanians discusses the benefits of oral versus injectable PCSK9s, as well as the ongoing research to clear enlicitide alone for cardiovascular indications.
Enlicitide, first approved by the US Food and Drug Administration (FDA) on July 16, 2026, to lower LDL-C in adults with hypercholesterolemia, became available for prescription in August; however, the drug’s lack of a cardiovascular indication limits its use beyond an addition to statins.1,2
Enlicitide is the first oral PCSK9 inhibitor to receive FDA approval – historically, they have only been available as injectables administered once or twice a month. A leading draw for enlicitide is the avoidance of treatment adherence issues raised by regular injections. Currently, however, it is only cleared as an add-on to statin therapy following evidence that statins alone are not sufficiently reducing LDL-C to the clinical target level.1,2
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